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The clone FUT4/815 recognizes CD15, a cell surface protein (~220kDa) abundantly expressed by granulocytes and monocytes. CD15 is 3-fucosyl-N-acetyllactosamine (3-FAL), also known as Lewis X, 3-FAL, X-hapten, and SSEA-1. CD15 plays important role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is also expressed by Langerhans cells and some malignant cells. CD15 antibody is very useful in the identification of Hodgkin’s Disease and large cell lymphomas of both B and T phenotypes.
Each lot of these antibodies has been pre-titrated and tested by flow cytometric analysis of human PBMCs such that 0.5μg (unconjugated, Biotin) or 5μl (conjugated) of these products are sufficient for staining 1 million cells in a 100μl staining volume or 100μl of whole blood. It is recommended to titrate antibody reactivity empirically for optimal performance. Do you need an antibody for an antigen you don't see on our website? Do you need a different conjugation than what we have listed? We have a wide selection of antigens with a variety of conjugations available. Please reach out to us at support@geneseesci.com.